Padrón Lab Publications
| Authors |
Title |
Reference |
Abstract | Type |
|
| Brito, R.,
Alamo, L., Lundberg, L, Guerrero, J.R., Pinto, A., Sulbarán, G.,
Gawinowicz, M. A., Craig, R. & Padrón, R. |
A molecular
model of phosphorylation-based activation and potentiation of tarantula
muscle thick filaments |
J. Mol.
Biol. http://dx.doi.org/10.1016/j.jmb.2011.09.017 |
PDF |
Abstract |
EM |
| Pradeep, L.,
Winkler, H., Taylor, K., Zoghbi, M., Craig, R., Padrón, R.,
Squire, J. & Liu, J |
Direct
visualisation of myosin binding protein C bridging myosin and actin
filaments in intact muscle |
Proc. Nat.
Acad. Sci. (USA): 108(28):11423-8, 2011 |
PDF |
Abtract |
EM |
| Rodriguez ,
R. & Padrón, R. |
Uso de la
genética en el diagnóstico de la miocardiopatía
hipertrófica familiar |
Avances Cardiol 31(1): 45 - 47, 2011 | PDF |
Abstract |
Review |
| Wriggers,
W., Alamo, R. & Padrón R. |
Matching
Structural Densities from Different Biophysical Origins with Gain and
Bias |
J. Struct.
Biol. : accepted for publication |
PDF |
Abstract |
Image
processing |
Alamo, L.,
Wriggers, W., Pinto, A., Bártoli, F., Salazar, L., Zhao, F.,
Craig, R. & Padrón, R. |
Three-dimensional
Reconstruction of Tarantula Myosin Filaments Suggests How
Phosphorylation May Regulate Myosin Activity |
J.
Mol.
Biol. 384: 780-797, 2008 |
PDF |
Abstract |
Cryo-EM |
| Luther,
P. K., Knupp,
C., Craig, R., Padrón, R., Harris, S., Patel, J., Moss, R. L. & Bennet, P. M. |
Understanding the organization and role of myosin binding protein C in striated muscle by analysis of normal and MyBPC knockout muscle. | J.
Mol.
Biol. 384: 60-72, 2008
|
PDF |
Abstract | EM |
| F. Q. Zhao, R. Padrón & R. Craig. | Blebbistatin stabilizes the helical order of myosin filaments by promoting the switch 2 closed state. | Biophys. J. 95: 3322-3329, 2008 |
PDF |
Abstract | EM |
| Padrón,
R. |
El mecanismo molecular de la regulación de la contracción muscular. | Arch. Ven. Farm Ter. 27(1): 2-4, 2008. | PDF |
- |
Review |
| Padrón,
R. |
Filamento
de miosina: modelo atómico |
Investigación y Ciencia 369: 28-30,
2007 (Spanish version of Scientific American) |
PDF |
- |
Brief
review |
Padrón,
R. & Alamo, L.  |
Review:
The use of negative staining and cryo-electron microscopy to understand
the molecular mechanism of myosin-linked regulation of striated muscle
contraction. |
Acta Microsc. 13: 14-29, 2004. (actually published in 2006!) |
Abstract | Review |
|
| Woodhead,
J., Zhao, F., Craig, R., Egelman, E., Alamo, L. & Padrón, R. |
Atomic model of a myosin filament in the relaxed state. | Nature 436: 1195-1199 , 2005. | PDF |
Supplementary
information |
Cryo-EM |
| Zoghbi,
M. E., Woodhead,J., Craig, R. & Padrón, R. |
Helical order in tarantula thick filaments requires the closed conformation of the myosin head. | J. Mol. Biol. 342: 1223-1236, 2004. | PDF |
Abstract | EM |
| Craig, R. & Padrón, R. | Molecular Structure of the Sarcomere | Chapter
7. text book “Myology” (Edit. A. G. Engel y C. Franzini-Armstrong), 3th edition. McGraw-Hill, Inc., New York. 2004. (invited review) |
PDF PDF mirror site |
text
book chapter |
|
| Ramírez,
C. D. & Padrón R. |
Cardiomiopatía hipertrófica familiar: genes, mutaciones y modelos animales. | Inv. Clin. 45(1): 69-100, 2004. | PDF HTML |
Review |
|
Luther,
P.K. , Padrón, R., Ritter, S, Craig, R. & Squire, J.
M.  |
Heterogeneity of Z-band structure within a single muscle sarcomere: Implications for sarcomere assembly. | J. Mol. Biol. 332: 161-169, 2003. | Abstract | EM |
|
| Hidalgo,
C., Padrón, R., Horowitz, R., Zhao, F. & Craig, R. |
Purification of native myosin filaments from muscle. | Biophys. J. 81: 2817-2826, 2001. | Abstract | Cryo-EM |
|
| Hidalgo,
C., Craig, R., Ikebe, M. & Padrón, R. |
Mechanism of phosphorylation of the regulatory light chain of myosin from tarantula striated muscle. | J. Muscle Res. Cell Motil. 22. 51-59, 2001. | Abstract | EM |
|
| Offer,
G.; Knight, P.; Burgess, S. A. Alamo, L. & Padrón, R. |
A new model for the surface arrangement of myosin molecules in heads in tarantula thick filaments. | J. Mol. Biol. 298: 239-260, 2000. | Abstract | EM |
|
| Padrón,
R.; Alamo, L.; Murgich, J. & Craig, R.  |
Towards an atomic model of the thick filament of muscle. | J. Mol. Biol. 275: 35-41, 1998. | Abstract | EM |
|
| Mateu,
L.; Moran, O.; Padrón, R., Borgo, M., Vonasek, E.,
Marquez, V. & Luzzati, V. |
The action of local anesthetics on myelin structure and nerve conduction in toad sciatic nerve. | Biophys. J.: 70: 2581-2587, 1997. | Abstract | X-ray |
|
| San-Blas,
G.; Padrón, R.; Alamo, L. & San-Blas, F. |
Use of morphology index histograms to quantify populations of the fungal pathogen Paracoccidioides brasiliensis. | Microbiology 143: 197-202, 1997. | Abstract | EM |
|
| Caputo,
C. & Padrón, R. |
Mecanismo de la contracción muscular | Cap.
26. Pp 610-647 Biofísica y Fisiología Celular (eds. Bezanilla, F., Latorre, R., López Barneo, J. y Llinás, R.) Universidad de Sevilla, Sevilla, España. 1996. |
Text
book chapter |
||
| Padrón,
R., Alamo, L., Guerrero, J. R., Granados, M., Uman, P. & Craig, R.  |
Three-dimensional reconstruction of thick filaments from rapidly frozen, freeze-substituted tarantula muscle. | J.
Struct. Biol.: 115(3): 250-257, 1995. |
Abstract | EM |
|
| Padrón,
R., Rodriguez, J.; Guerrero, J. R. & Alamo, L. |
Fraying of thick filaments from tarantula muscle into subfilaments. | Acta Microsc. 2(1): 85-92, 1993. | PDF |
EM |
|
| Padrón,
R., Guerrero, J. R., Alamo, L., Granados, M., Gherbesi,
N. & Craig, R. |
Direct visualization of myosin filament symmetry in tarantula striated muscle by electron microscopy. | J. Struct. Biol.: 111: 17-21, 1993. | EM |
||
| Craig,
R., Alamo, L. & Padrón, R. |
Structure of the myosin filaments of relaxed and rigor striated vertebrate muscle studied by rapid freezing electron microscopy. | J. Mol. Biol. 228: 474-487, 1992. | EM |
||
| Guerrero,
J. R. & Padrón, R. |
The Substructure of the backbone of the thick filament from Tarantula muscle. | Acta Microsc. 1(2): 63-83, 1992. | PDF |
EM |
|
| Padrón,
R.; Granados, M.; Alamo, L.; Guerrero, J. R. & Craig, R. |
Visualization of myosin helices in sections of rapidly frozen relaxed tarantula muscle. | J. Struct. Biol. 108(3): 269-276, 1992. | EM |
||
| Alamo,
L., Padrón, R., Craig, R. & Hidalgo, C.  |
Método para la determinación directa de la simetría rotacional de filamentos gruesos de músculo por procesamiento digital de imágenes. | Acta Cient. Ven. 42(2): 59-63, 1991. | EM |
||
| Craig,
R., Padrón, R. & Alamo, L. |
Direct determination of myosin filament symmetry in scallop striated adductor muscle by rapid freezing and freeze-substitution. | J. Mol. Biol. 220: 125-132,1991. | EM |
||
| Padrón,
R., Panté, N., Sosa, H. & Kendrick-Jones, J. |
X-ray diffraction study of the structural changes accompanying phosphorylation of tarantula muscle. | J.
Muscle Res. Cell Motil. 12(3): 235-241, 1991. |
Abstract | X-ray |
|
| Padrón, R. & Craig, R. | Disorder induced in non-overlap myosin crossbridges by loss of adenosine triphosphate. | Biophys. J. 56: 927-933, 1989. | EM |
||
| Panté,
N., Sosa, H. &
Padrón, R. |
Estudio por difracion de rayos-X de los cambios estructurales que acompañan la fosforilación de los filamentos gruesos de músculo de tarántula. | Acta Cient. Ven. 39(3): 230-236, 1988. | X-ray |
||
| Padrón,
R., Alamo, L. Craig, R. & Caputo, C. |
A method for quick-freezing live muscles at known instants during contraction with simultaneous recording of mechanical tension. | J. Microsc. (Oxford) 151: 81-102, 1988. | EM |
||
Sosa,
H., Panté, N. & Padrón, R.  |
Análisis de la sección ecuatorial del patrón de difracción de rayos-X de músculos estriados de tarántula en diferentes condiciones experimentales. | Acta Cient. Ven. 39(1): 51-59, 1988. | X-ray |
||
| Alamo,
L., Padrón, R., Craig, R. & Caputo, C. |
Método para el congelamiento rápido con nitrógeno o helio líquido de músculos en contracción tetánica. | Acta Cient. Ven. 38(4): 513-514, 1987. | EM |
||
| Martelo,
M.J. & Padrón, R. |
Método rápido para el aislamiento y purificación de miosina de músculo de tarantula. | Acta Cient. Ven. 38(3): 394-395, 1987. | BC |
||
| Padrón,
R., Queralt, V. & Sosa, H. |
Método para la cuantificación de cambios en la capacidad de retención de agua en carne utilizando difracción de rayos-X. | Acta Cient. Ven. 38(2): 287-288, 1987. | X-ray |
||
| Craig,
R., Padrón, R. & Kendrick-Jones: |
Structural changes accompanying phosphorylation of tarantula muscle thick filaments. | J. Cell. Biol. 105: 1319-1327, 1987. | EM |
||
| Sosa,
H., Panté, N., & Padrón, R. |
Determinación de la sección ecuatorial del patrón de difracción de rayos-X de músculo vivo de tarántula. | Acta Cient. Ven. 37(5): 587-588, 1986. | X-ray |
||
| Panté,
N., Sosa, H.& Padrón, R. |
Predicción de cambios relativos en el patrón ecuatorial de difracción de rayos-X de músculo estriado causados por la activación de la contracción muscular. | Acta Cient. Ven. 37: 223-225, 1986. | X-ray |
||
| Crowther,
R.A.; Padrón, R. & Craig, R.: |
The arrangement of the heads of myosin in relaxed thick filaments from Tarantula muscle. | J. Mol. Biol. 184(3): 429-439, 1985. | EM |
||
| Padrón,
R. & Huxley, H.E. |
The effect of the ATP analogue AMPPNP on the structure of crossbridges in vertebrate skeletal muscle: X-ray diffraction and mechanical studies. | J. Muscle Res. Cell. Motil 5(6): 613-655, 1984. | X-.ray |
||
| Egelman,
E.H. & Padrón, R. |
X-ray diffraction evidence that actin is a 100 Å filament. | Nature, 307: 56-58, 1984. | X-ray |
||
| Padrón,
R. & Mateu, L. |
Repetitive propagation of action potentials destabilizes the structure of the myelin sheath: a dynamic X-ray diffraction study. | Biophys. J. 39: 183-188, 1982. | X-ray |
||
| Padrón,
R. & Mateu, L. |
Alteración reversible de la estructura de las membranas de mielina de nervio ciático de rana por comprensión mecánica in vivo: estudio por difracción de rayos-X. | Acta Cient. Venez. 32(2): 166-171, 1981. | X-ray |
||
| Padrón,
R. & Mateu, L. |
In vivo structure of frog sciatic nerve myelin membranes: a X-ray diffraction study at 13 Å resolution. | J. Neurosc. Res. 6(2): 251-260, 1981. | X-ray |
||
| Padrón,
R. & Mateu, L. |
The effect of repetitive propagation of action potentials on the structure of toad sciatic nerve myelin membranes: a X-ray diffraction study at 11 Å resolution. | J. Neurosc. Res. 5(6): 611-620, 1980. | X-ray |
||
| Padrón,
R., Salas, R. & Mateu, L. |
La estructura de las membranas de mielina de nervio ciático de rana: determinación in vivo por difracción de rayos-X a 15 Å de resolución espacial. | Acta Cient. Venez. 31(3): 224-228, 1980. | X-ray |
||
| Padrón,
R. & Caputo, C. |
Canonical equivalent circuits of isolated barnacle muscle fibers. | Acta Cient. Venez. 31(2): 160-166, 1980. | EP |
||
| Padrón,
R., Mateu, L. & Requena, J. |
A dynamic X-ray diffraction study of anesthesia action: Changes in myelin structure and electrical activity recorded simultaneously from frog sciatic nerves treated with n-alkanes. | Biochim. Biophyhs. Acta 602: 221-233, 1980. | X-ray |
||
| Padrón,
R., Mateu, L. & Kirschner, D.A. |
X-ray diffraction study of the kinetics of myelin lattice swelling: the effect of divalent cations. | Biophys. J. 28: 231-239, 1979. | X-ray |
||
| Padrón, R., Requena, J. & Mateu, L. | A dynamic X-ray diffraction study of anesthesia action: Thickening of the myelin membrane by n-pentane. | Biochim. Biophys. Acta 552: 535-539, 1979. |
X-ray |
||
| Padrón,
R. |
Alteración de la estabilidad estructural de la mielina: Estudio por difracción de rayos-X. | Tesis de Grado para optar al Título de Ph.Sc. en Biología, mención Fisiología y Biofísica. Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Estudios Avanzados (CEA), 1979. | X-ray |
||
| Mateu,
L., Kirchhausen, T., Padrón, R. & Camejo, G. |
Small-angle X-ray scattering study of human serum low density lipoproteins with differential reactivity for an arterial proteoglycan. | J. Supramol. Struct. 7: 435-442, 1977. | X-ray |
||
| Padrón,
R. |
La estabilidad estructural de la mielina: Estudio por difracción de rayos-X. | Trabajo de Grado para optar al Título de M.Sc. en Biología, mención Fisiología y Biofísica. Instituto Venezolano de Investigaciones Científicas (IVIC), Centro de Estudios Avanzados (CEA), 1977. | X-ray |
||
| Camejo,
G., Mateu, L., Lalaguna, F., Padrón, R., Waich, A.,
Aquatella, H. & Vega, H. |
Structural individuality of human serum LDL associated with a differential affinity for a macromolecular component of the arterial wall. | Artery 2(1): 79-97, 1976. | X-ray |
||
| Padrón,
R. |
Propiedades eléctricas pasivas de fibras musculares aisladas de Balanus. | Trabajo Especial para optar al Título de Ingeniero Eléctrico. Universidad Central de Venezuela (UCV), Facultad de Ingeniería, 1974. | EP |